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Interactions between cytochromes P450, glutathione S-transferases and Ghanaian medicinal plantsAPPIAH-OPONG, Regina; COMMANDEUR, Jan N. M; AXSON, Civianny et al.Food and chemical toxicology. 2008, Vol 46, Num 12, pp 3598-3603, issn 0278-6915, 6 p.Article

Comparative cytotoxicity of N-substituted N'-(4-imidazole-ethyl)thiourea in precision-cut rat liver slicesONDERWATER, Rob C. A; COMMANDEUR, Jan N. M; VERMEULEN, Nico P. E et al.Toxicology (Amsterdam). 2004, Vol 197, Num 2, pp 81-91, issn 0300-483X, 11 p.Article

Characterization of thioether compounds formed from alkaline degradation products of enfluraneORHAN, Hilmi; VERMEULEN, Nico P. E; SAHIN, Gonul et al.Anesthesiology (Philadelphia). 2001, Vol 95, Num 1, pp 165-175, issn 0003-3022Article

Structure-activity relationships for the inhibition of recombinant human cytochromes P450 by curcumin analoguesAPPIAH-OPONG, Regina; DE ESCH, Iwan; COMMANDEUR, Jan N. M et al.European journal of medicinal chemistry. 2008, Vol 43, Num 8, pp 1621-1631, issn 0223-5234, 11 p.Article

Evaluation of a novel high-throughput assay for cytochrome P450 2D6 using 7-methoxy-4-(aminomethyl)-coumarinVENHORST, Jennifer; ONDERWATER, Rob C. A; MEERMAN, John H. N et al.European journal of pharmaceutical sciences. 2000, Vol 12, Num 2, pp 151-158, issn 0928-0987Article

Efficient Screening of Cytochrome P450 BM3 Mutants for Their Metabolic Activity and Diversity toward a Wide Set of Drug-Like Molecules in Chemical SpaceREINEN, Jelle; VAN LEEUWEN, Jolanda S; LI, Yongmin et al.Drug metabolism and disposition. 2011, Vol 39, Num 9, pp 1568-1576, issn 0090-9556, 9 p.Article

Development of three parallel cytochrome P450 enzyme affinity detection systems coupled on-line to gradient high-performance liquid chromatographyKOOL, Jeroen; VAN LIEMPD, Sebastiaan M; VAN ROSSUM, Huub et al.Drug metabolism and disposition. 2007, Vol 35, Num 4, pp 640-648, issn 0090-9556, 9 p.Article

Induction of glutathione-S-transferase mRNA levels by chemopreventive selenocysteine Se-conjugates'T HOEN, Peter A. C; ROOSEBOOM, Martijn; BIJSTERBOSCH, Martin K et al.Biochemical pharmacology. 2002, Vol 63, Num 10, pp 1843-1849, issn 0006-2952Article

Regio- and Stereoselective Hydroxylation of Optically Active α-Ionone Enantiomers by Engineered Cytochrome P450 BM3 MutantsVENKATARAMAN, Harini; DE BEER, Stephanie B. A; GEERKE, Daan P et al.Advanced synthesis & catalysis (Print). 2012, Vol 354, Num 11-12, pp 2172-2184, issn 1615-4150, 13 p.Article

Diclofenac Inhibits Tumor Necrosis Factor-α-Induced Nuclear Factor-κB Activation Causing Synergistic Hepatocyte ApoptosisFREDRIKSSON, Lisa; HERPERS, Bram; DE GRAAUW, Marjo et al.Hepatology (Baltimore, Md.). 2011, Vol 53, Num 6, pp 2027-2041, issn 0270-9139, 15 p.Article

Determination and identification of estrogenic compounds generated with biosynthetic enzymes using hyphenated screening assays, high resolution mass spectrometry and off-line NMRDE VLIEGER, Jon S. B; KOLKMAN, Ard J; AMPT, Kirsten A. M et al.Journal of chromatography. B. 2010, Vol 878, Num 7-8, pp 667-674, issn 1570-0232, 8 p.Article

Metabolic regio- and stereoselectivity of cytochrome P450 2D6 towards 3,4-methylenedioxy-N-alkylamphetamines : In silico predictions and experimental validationKEIZERS, Peter H. J; DE GRAAF, Chris; DE KANTER, Frans J. J et al.Journal of medicinal chemistry (Print). 2005, Vol 48, Num 19, pp 6117-6127, issn 0022-2623, 11 p.Article

An on-line post-column detection system for the detection of reactive-oxygen-species-producing compounds and antioxidants in mixturesKOOL, Jeroen; VAN LIEMPD, Sebastiaan M; HARMSEN, Stefan et al.Analytical and bioanalytical chemistry. 2007, Vol 388, Num 4, pp 871-879, 9 p.Article

Influence of phenylalanine 120 on cytochrome P450 2D6 catalytic selectivity and regiospecificity: crucial role in 7-methoxy-4-(aminomethyl)-coumarin metabolismKEIZERS, Peter H. J; LUSSENBURG, Barbara M. A; DE GRAAF, Chris et al.Biochemical pharmacology. 2004, Vol 68, Num 11, pp 2263-2271, issn 0006-2952, 9 p.Article

Identification of critical residues in novel drug metabolizing mutants of cytochrome P450 BM3 using random mutagenesisVAN VUGT-LUSSENBURG, Barbara M. A; STJERNSCHANTZ, Eva; LASTDRAGER, Jeroen et al.Journal of medicinal chemistry (Print). 2007, Vol 50, Num 3, pp 455-461, issn 0022-2623, 7 p.Article

Rapid on-line profiling of estrogen receptor binding metabolites of tamoxifenKOOL, Jeroen; RAMAUTAR, Rawi; VAN LIEMPD, Sebastiaan M et al.Journal of medicinal chemistry (Print). 2006, Vol 49, Num 11, pp 3287-3292, issn 0022-2623, 6 p.Article

Homology modeling of rat and human cytochrome P450 2D (CYP2D) isoforms and computational rationalization of experimental ligand-binding specificitiesVENHORST, Jennifer; TER LAAK, Antonius M; COMMANDEUR, Jan N. M et al.Journal of medicinal chemistry (Print). 2003, Vol 46, Num 1, pp 74-86, issn 0022-2623, 13 p.Article

Selective induction of cytochrome P450 3A1 by dexamethasone in cultured rat hepatocytes : Analysis with a novel reverse transcriptase-polymerase chain reaction assayHOEN, Peter A. Chr'T; COMMANDEUR, Jan N. M; VERMEULEN, Nico P. E et al.Biochemical pharmacology. 2000, Vol 60, Num 10, pp 1509-1518, issn 0006-2952Article

Role of Residue 87 in the Activity and Regioselectivity of Clozapine Metabolism by Drug-Metabolizing CYP102A1 M11H: Application for Structural Characterization of Clozapine GSH ConjugatesSREA, Vanina; DRAGOVIC, Sanja; BOERMA, Jan Simon et al.Drug metabolism and disposition. 2011, Vol 39, Num 12, pp 2411-2420, issn 0090-9556, 10 p.Article

Automated detection of covalent adducts to human serum albumin by immunoaffinity chromatography, on-line solution phase digestion and liquid chromatography-mass spectrometryHOOS, Johannes S; DAMSTEN, Micaela C; DE VLIEGER, Jon S. B et al.Journal of chromatography. B. 2007, Vol 859, Num 2, pp 147-156, issn 1570-0232, 10 p.Article

Inhibition of human recombinant cytochrome P450s by curcumin and curcumin decomposition productsAPPIAH-OPONG, Regina; COMMANDEUR, Jan N. M; VAN VUGT-LUSSENBURG, Barbara et al.Toxicology (Amsterdam). 2007, Vol 235, Num 1-2, pp 83-91, issn 0300-483X, 9 p.Article

Liquid chromatography/tandem mass spectrometry detection of covalent binding of acetaminophen to human serum albuminDAMSTEN, Micaela C; COMMANDEUR, Jan N. M; FIDDER, Alex et al.Drug metabolism and disposition. 2007, Vol 35, Num 8, pp 1408-1417, issn 0090-9556, 10 p.Article

Surface-enhanced resonance raman scattering of cytochrome P450-2D6 on coated silver hydrosolsBONIFACIO, Alois; KEIZERS, Peter H. J; VERMEULEN, Nico P. E et al.Langmuir. 2007, Vol 23, Num 4, pp 1860-1866, issn 0743-7463, 7 p.Article

The role of phenylalanine 483 in cytochrome P450 2D6 is strongly substrate dependentLUSSENBURG, Barbara M. A; KEIZERS, Peter H. J; DE GRAAF, Chris et al.Biochemical pharmacology. 2005, Vol 70, Num 8, pp 1253-1261, issn 0006-2952, 9 p.Article

Influence of n-substitution of 7-methoxy-4-(aminomethyl)-coumarin on cytochrome P450 metabolism and selectivityVENHORST, Jennifer; ONDERWATER, Rob C. A; MEERMAN, John H. N et al.Drug metabolism and disposition. 2000, Vol 28, Num 12, pp 1524-1532, issn 0090-9556Article

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